Azza El Medany

University of Alexandria
Egypt

Abstract Title: What is the possible therapeutic effect of ginkgo biloba on gastric ulcer induced by ammonia in albino rats?

Biography: Professor Azza El-Medany Bachelor of Medicine, University of Alexandria. Master Degree in Basic Medical Science in Pharmacology and completed her PhD at age of 32 years from Alexandria University and postdoctoral studies from Alexandria University College of Medicine. She was a Prof. of clinical pharmacology & therapeutics &Vice head of department of pharmacology, She published more than 40 papers in the areas of GIT, CVS, Natural products & toxicological researches in reputed journals and serving as a memberships of a number of Professional Bodies, was a speaker in a number of international conferences, the last ones in Singapore , Japan , Brazil & USA, Malysia & Australia. She is a recipient of special awards in scientific research & teaching.

Research Interest: Gastric ulcer is worldwide disease. Helicobacter pylori is one of the most common chronic bacterial infections that induce chronic inflammation in the gastric mucosa, mediated by an array of pro-and inflammatory cytokines. The aim of this study was to investigate the possible therapeutic effects of ginkgo biloba extract on gastric ulcer induced by ammonium hydroxide in rats and the potential underlying mechanisms. Methods: The study was done on 32 adult male wister rats , divided equally into 4 groups ; normal control, gastric ulcer induced group using 1ml of 1% NH4OH orally, untreated rats were received 1% carboxymethyl cellulose and treated rats received orally 200mg/kg ginkgo biloba once daily for 14 days. Results: The study revealed administration of ammonia showed multiple gastric lesions; edema, hyperemia , hemorrhage and ulcers with significant increase in ulcer score, myeloperoxidase (MPO ), interleukin-1β (IL-1β) and significant decrease in reduced glutathione (GSH), mucus amount and gastric PH. Conclusions: after the administration of Ginkgo biloba, there was improved in gastric lesions, with significant reduction of ulcer score, MPO, IL-1β and significant increase in GSH, mucus content and gastric PH. Moreover, collagen type I & IV were gradually increased in treated group. The obtained data could conclude that ginkgo biloba extract is suitable for therapeutic use against H. pylori and gastric ulcer may be due to its anti-inflammatory, anti-secretory ,preserving gastric mucus, GSH , and or gastric cell proliferation and collagen deposition. Finally , although , this pilot study pointed to an advanced trend of investigation more studies at animal level and on volunteers must be carried out to explain exactly its clinical effect.