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Bo-In Kwon

 

Bo-In Kwon

Sangji University
South Korea

Abstract Title: Sojadodamganggi-tang attenuates allergic lung inflammation by inhibiting T helper 2 cells and Augmenting alveolar macrophages

Biography:

Bo-In Kwon has completed his PhD at the age of 30 years from KAIST Worked as a Senior Researcher at the Korea Institute of Oriental Medicine. He is the Aof XXXX, a premier Bio-Soft service organization. He has published more than 25 papers in reputed journals and has been serving as an editorial board member of repute.

Research Interest:

Asthma is a chronic respiratory hypersensitivity disorder whose prevalence has rapidly increased due to environmental pollution, fine particulate matter, and dietary changes. Although bronchodilators and corticosteroids are widely used for asthma treatment, these therapies are mainly symptomatic, may cause adverse effects, and are ineffective in some patients. Sojadodamganggi-tang, a traditional herbal prescription used to relieve cough and sputum, has been clinically utilized for many years; however, its immunological mechanisms and therapeutic efficacy have not been fully elucidated. In this study, we investigated the anti-asthmatic effects of Sojadodamganggi-tang using an ovalbumin (OVA)-induced acute asthma mouse model. Balb/c mice were sensitized by intraperitoneal injection of OVA followed by intranasal OVA administration. Animals were divided into four groups: saline control, asthma + vehicle, asthma + Sojadodamganggi-tang, and asthma + dexamethasone. A standardized herbal extract provided by the Korea Institute of Oriental Medicine was orally administered at 200 mg/kg. Bronchoalveolar lavage fluid (BALF) and lung tissues were collected to analyze inflammatory mediators and immune cell populations. Treatment with Sojadodamganggi-tang significantly reduced eosinophil infiltration and inflammatory cell counts in BALF compared with the vehicle group. ELISA analysis demonstrated decreased levels of interleukin-13 (IL-13), a key Th2-associated cytokine in allergic asthma. Flow cytometric analysis also revealed reduced populations of Th2 cells and eosinophils in lung tissues. These findings suggest that Sojadodamganggi-tang exerts therapeutic effects in allergic asthma through suppression of Th2-mediated immune responses.