Pargat Singh

Chitkara College of Pharmacy
India

Abstract Title: Oregano-Derived Phytoconstituents with Potential Antidepressant Mechanisms: An Overview

Biography: Pargat Singh is pursuing PhD in Pharmaceutical Sciences at Chitkara University. His Research Topic is ‘Phytochemical and Anti-Depressant Activity of Origanum vulgare leaves from family Lamiaceae’. He has 4 years Research experience in depression related study on Plants. He has published 5 papers in reputed journals.

Research Interest: One of the most common and incapacitating disorder affecting both individuals and the general public globally is major depression. By 2030, it is predicted to rank first among the factors affecting the burden of illness worldwide. Both Indian and foreign flora contain a number of herbs that can be utilized to treat depression with little to no negative side effects. However, there are still numerous genera in the vivid plant family that are poorly or inadequately explored, and the effectiveness of these plants in treating depression has not yet been established. Plant phytoconstituents offer a natural way to treat depression by concentrating on multiple pathways, including neurotransmitter modulation, neuroprotection, anti-inflammatory effects, oxidative stress reduction, gut microbiota balance, and stress hormone management. The potential of major phytoconstituents found in Origanum vulgare, a plant belonging to the Lamiaceae family is the main topic of this review, which is based on the reviewed literature and the availability of raw materials. This article compiles the phytoconstituents including polyphenols, phytosterols and pentacyclic triterpenoids found in Origanum vulgare that have been shown to have antidepressant effects throughout the past five years (2019–2025) in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. This study attempts to establish the link between these compounds and depression by reviewing available data from preclinical in vivo studies, observational and interventional research, systematic literature reviews, and meta-analyses of human observational and interventional studies.